Ask The Experts: Tdap for Adolescents & Adults | Immunize.org (2024)

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What is the difference between the two Tdap products – Boostrix and Adacel? I am confused about which adults to vaccinate with Tdap vaccine and which product to use. Please help! We see many 10-year-olds for middle school entry immunization. Is one brand of Tdap preferred for this age group? ACIP states that children up to date on vaccines who receive a Tdap vaccine when 7–9 years old should receive another Tdap dose at age 11 or 12 years old. What about a child who is 10 years old? We have a 13-year-old patient who was given DT (pediatric) as a preschooler after she had experienced excessive crying following a dose of DTP. Now, we are wondering if we can give her Tdap since we know she may not be protected against pertussis. Should I make an effort to give teenagers a Tdap dose, even if they’ve had a dose of Td at age 11–12 years? We have a 16-year-old patient who received tetanus-diphtheria (Td) vaccine in the emergency room after a nail puncture a year ago. He has never had a tetanus-diphtheria-acellular pertussis (Tdap) vaccine. Can we give him a Tdap vaccine now? Some children in my practice are not up to date on their immunizations, and pertussis is circulating in our community. Can you guide me in determining how to make the decision about which vaccine to choose? I need to know how to catch-up a child who is 12 years old and received 1 dose of DTaP vaccine at age 2 years and a dose of Tdap at age 11 years. A 16-year-old has a written record of receiving two doses of DTaP at 2 and 5 months of age and one dose of Tdap at 15 years of age. Since she has had three doses of pertussis-containing vaccine, would she still need two additional doses of Td? According to the ACIP recommendations, which healthcare personnel should be vaccinated against pertussis with tetanus-diphtheria-acellular pertussis (Tdap) vaccine? Instead of giving tetanus/diphtheria toxoid and acellular pertussis (Tdap) vaccine to a father-to-be that needed protection against pertussis, we mistakenly gave him tetanus/diphtheria (Td) toxoid. How soon after the Td dose can we give him the dose of Tdap he needs? Can a booster dose of Tdap be given to people age 65 years and older? Please review the current recommendations for the use of Tdap in adults. Is there an upper age limit for Tdap administration? For example, should I vaccinate an 85-year-old? For a person entering a long-term-care facility at age 70 or older, if we cannot document that the resident has had a primary series of three doses of tetanus-containing vaccine, is the right course of action upon admission to give a Tdap first, then a Td or Tdap in 1 to 2 months, followed by a Td or Tdap in 6 to 12 months, and then a Td or Tdap booster every 10 years? If a teen or adult patient never received Tdap but received a dose of Td vaccine 2 years ago, should I wait 8 more years before administering a dose of Tdap to the patient? If a teen or adult mistakenly received a dose of Td when they should have received Tdap, what is the optimal time to give the missing Tdap dose? Can the parents of a young infant be given a dose of Tdap right after birth to protect themselves and, indirectly, their newborn from pertussis, even though they had a dose of Td vaccine less than two years ago? Can Tdap be given at the same visit as other vaccines? Someone in our clinic gave DTaP to a 50-year-old instead of Tdap. How should this be handled? A pertussis outbreak is occurring in our town, with many cases happening in the schools. Is there a recommendation for boosting middle- and high-school students with an additional dose of Tdap during an outbreak if students have already had 1 dose?

Home / Ask the Experts / Diphtheria / Tdap for Adolescents & Adults

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Both of these vaccines provide protection against diphtheria, tetanus, and pertussis. Boostrix (GSK) is licensed for people ages 10 years and older, and Adacel (Sanofi Pasteur) is licensed for people ages 10 through 64 years. The two vaccines also contain a different number of pertussis antigens and different concentrations of pertussis antigen and diphtheria toxoid.

Last reviewed: March 31, 2022

Updated ACIP recommendations for the use of Tdap were published in April 2018 (available at www.cdc.gov/mmwr/volumes/67/rr/pdfs/rr6702a1-H.pdf) and January 2020 (available at www.cdc.gov/mmwr/volumes/69/wr/pdfs/mm6903a5-H.pdf). ACIP recommends that all adults age 19 years and older who have not yet received a dose of Tdap receive a single dose. Tdap should be administered regardless of interval since the last tetanus or diphtheria toxoid-containing vaccine (e.g., Td). After receiving Tdap, people should receive Td or Tdap every 10 years for routine booster immunization against tetanus and diphtheria, according to previously published guidelines. A dose of Tdap should be administered during each pregnancy, preferably early in the 27 week through 36 week gestation time period.

Providers should not miss an opportunity to vaccinate adults age 65 and older with Tdap. Providers may administer any Tdap vaccine they have available. When feasible, providers should administer Boostrix (GSK) to adults age 65 and older as it is licensed for this age group. Adacel (Sanofi) is licensed for use in people age 10 through 64. However, ACIP concluded that either vaccine administered to a person age 65 or older is immunogenic and will provide protection. A dose of either vaccine is considered valid.

When a tetanus toxoid-containing vaccine is needed for wound management in a person who has not previously received Tdap, the use of Tdap is preferred over Td.

Last reviewed: March 31, 2022

No. In March 2014, FDA lowered the age indication for Adacel brand Tdap vaccine (Sanofi) from age 11 years to age 10 years. Both Tdap products, Adacel and Boostrix (GSK), now have the same lower age indication.

Last reviewed: March 31, 2022

Tdap vaccination for adolescents is recommended at age 11–12 years. A 10-year-old who is already up to date on diphtheria/tetanus/pertussis vaccines and gets a Tdap vaccine for any reason does not need to receive another Tdap at age 11–12 years.

Last reviewed: March 31, 2022

Yes, you can. Many of the conditions previously considered to be precautions to DTaP (e.g., temperature of 105°F or higher, collapse or shock-like state, persistent crying lasting 3 hours or longer, seizure with or without fever) did not apply to Tdap. These conditions are also no longer considered to be precautions to DTaP. This issue is addressed in the current ACIP statement, available at www.cdc.gov/mmwr/volumes/67/rr/pdfs/rr6702a1-H.pdf, page 3.

Last reviewed: March 31, 2022

Yes. All adolescents should receive one dose of Tdap vaccine to protect them from pertussis, even if they have already received Td. It is important to do this right away (no minimal interval is required), especially if they are in contact with an infant younger than age 12 months, work in a healthcare setting where they have direct contact with patients, or live in a community where pertussis is occurring.

Last reviewed: March 31, 2022

Yes. There is no need to observe any minimum interval between doses of Td and Tdap except when administered as part of a catch-up primary series of tetanus vaccine.

Last reviewed: March 31, 2022

You should use DTaP to catch up children younger than age 7 years. In addition, ACIP recommends giving one dose of Tdap to children age 7–10 years who were not fully vaccinated against pertussis before their seventh birthday. Children age 7–10 who require more than one dose of tetanus-containing vaccine to be up to date with diphtheria or tetanus immunization may be given either Td or Tdap for doses needed after the initial Tdap dose. Although this is an off-label use of the vaccines, it’s important that you vaccinate these unvaccinated or undervaccinated older children with Tdap as well as any other adolescent or adult who hasn’t received Tdap previously.

Last reviewed: May 30, 2024

This child needs to complete the primary series with 1 dose of Td or Tdap, administered no earlier than 6 months after the Tdap dose given at age 11 years. After that, the child needs a booster dose of Td or Tdap every 10 years. An easy way to determine how to catch up a child is to consult “Recommended Immunization Schedules for Persons Aged 0 Through 18 Years, U.S.” The schedule is approved by CDC, AAP, and AAFP and is released early in each calendar year. It includes a catch-up schedule for children who have fallen behind (see www.cdc.gov/vaccines/schedules/index.html).

Last reviewed: March 31, 2022

Since the first DTaP was received before 12 months of age and one Tdap dose has been given, this person needs one dose of Td or Tdap 6 calendar months after the Tdap dose. A routine Td or Tdap booster should be administered every 10 years. See Immunize.org’s handout: DTaP, Tdap, and Td Catch-up Vaccination Recommendations by Prior Vaccine History and Age: www.immunize.org/catg.d/p2055.pdf.

Last reviewed: March 31, 2022

ACIP recommends the following for the use of Tdap in healthcare personnel:

  • All healthcare personnel (HCP), regardless of age, should receive a single dose of Tdap as soon as feasible if they have not previously received Tdap and regardless of the time since last Td dose.
  • Tdap may be administered in any situations where Td only was previously recommended. After receipt of Tdap, HCP should receive routine booster immunization against tetanus and diphtheria with either Td or Tdap vaccine. Additionally, pregnant HCP should receive a dose of Tdap during each pregnancy.
  • Hospitals and ambulatory-care facilities should provide Tdap for HCP and use approaches that maximize vaccination rates (e.g., education about the benefits of vaccination, convenient access, and the provision of Tdap at no charge).

To view updated recommendations on the use of Td or Tdap in situations where only Td was previously recommended, go to www.cdc.gov/mmwr/volumes/69/wr/pdfs/mm6903a5-H.pdf. For details about Tdap and other recommendations for healthcare personnel, go to “Immunization of Health-Care Personnel” (MMWR 2011;60[SS-7]:4-46) at www.cdc.gov/mmwr/pdf/rr/rr6007.pdf.

Last reviewed: March 31, 2022

There is no minimum period to wait to correct your error. If you had immediately realized that you had mistakenly given the father-to-be Td instead of Tdap, you could have given him the needed Tdap dose at the same visit at which you gave him the erroneous Td dose.

Last reviewed: March 31, 2022

Yes. ACIP recommends a dose of Tdap be given to all adults, including those age 65 years or older.

Last reviewed: March 31, 2022

ACIP recommends the following:

  • All adults age 19 years and older who have not yet received a dose of Tdap should receive a dose.
  • All pregnant people should receive a dose of Tdap during each pregnancy, preferably between 27 and 36 weeks’ gestation. Mothers who have never received Tdap and who do not receive it during pregnancy should receive it immediately postpartum.
  • A person who has not yet received a dose of Tdap can be given a dose of Tdap regardless of the interval since the person last received a tetanus or diphtheria toxoid-containing vaccine.
  • Providers should not miss an opportunity to vaccinate adults age 65 years and older with Tdap. When feasible, give Boostrix to adults age 65 and older. However, either vaccine product (Adacel or Boostrix) provides protection and is considered valid for use in people in this age group.
  • For adults not previously vaccinated with Tdap who need wound management care to prevent tetanus, Tdap is preferred over Td.
  • For adults who have received an initial dose of Tdap, Tdap may be administered in any situations where Td only was previously recommended, including as the decennial (every 10-years) booster dose.

Last reviewed: March 31, 2022

There is no upper age limit for Tdap vaccination. A dose of Tdap is recommended for all adults. In addition, Tdap may be administered in any situations where Td only was previously recommended.

Last reviewed: March 31, 2022

Your understanding of the general Td/Tdap recommendation is correct, and this is the schedule that should be followed for persons 7 years old and older who have never received tetanus-containing vaccine or who cannot provide documentation of prior vaccination. ACIP recommends that Tdap or Td may be used in situations when only Td was previously recommended. Be sure to document doses administered in your state’s immunization information system so other healthcare providers will have access to the record of immunization and a primary series will not need to be repeated in the future.

Last reviewed: March 31, 2022

No. ACIP recommends that people age 11 years and older who have not yet received Tdap receive a dose of Tdap now. ACIP specifies no waiting interval between administering Td and Tdap.

Last reviewed: March 31, 2022

As soon as possible, even if it is the same day.

Last reviewed: March 31, 2022

Vaccination of the parents against pertussis after the baby is born is not optimal, but it may be helpful and should be done if the parents have not previously received Tdap, regardless of when they last received Td vaccination. It takes about 2 weeks after Tdap receipt for the parents to have protection against pertussis. Once the parents have protection, they are is less likely to transmit pertussis to the infant. However, the newborn remains at risk of contracting pertussis from others, including siblings, grandparents, and other caregivers. They should be counseled about the importance of Tdap vaccination of the mother during future pregnancies. See CDC’s web page for more information: www.cdc.gov/pertussis/pregnant/hcp/pregnant-patients.html.

Last reviewed: March 31, 2022

Yes. Tdap can be administered with all other vaccines that are indicated (e.g., meningococcal conjugate vaccine, hepatitis B vaccine, MMR). Each vaccine should be administered at a different anatomic site using a separate syringe.

Last reviewed: March 31, 2022

The DTaP recipient received the appropriate amount of tetanus toxoid and MORE diphtheria toxoid and pertussis antigen than is recommended. Count the dose as Tdap, but take measures to prevent this error in the future. The patient does not need a repeat dose of Tdap.

Last reviewed: March 31, 2022

Revaccination of individuals who are up to date on Tdap immunization with an additional dose of Tdap during a pertussis outbreak is currently not recommended.

Last reviewed: March 31, 2022

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Ask The Experts: Tdap for Adolescents & Adults | Immunize.org (2024)
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